Document 0069 DOCN M9490069 TI Seroepidemiological associations between tuberculosis, malaria, hepatitis B, and AIDS in West Africa. DT 9411 AU Adebajo AO; Smith DJ; Hazleman BL; Wreghitt TG; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge,; United Kingdom. SO J Med Virol. 1994 Apr;42(4):366-8. Unique Identifier : AIDSLINE MED/94322017 AB Serum samples from 51 patients with malaria, 35 patients with hepatitis B virus infection, 111 patients with tuberculosis, and 166 healthy controls were studied to determine any associations between tuberculosis, malaria, hepatitis B, and AIDS in Nigeria, West Africa. All serum samples were examined for the presence of HIV-1/HIV-2, hepatitis B virus surface antigen (HBsAg), and malaria antibodies. Only one patient was HIV-1 antibody-positive and none HIV-2 antibody-positive. Statistical associations were found between the presence of malaria antibody titres on the one hand and a diagnosis of hepatitis B virus infection (P < 0.05) or tuberculosis (P < 0.05). A stronger association (P < 0.001) was found between the presence of HBsAg and tuberculosis suggesting that HBsAg carriers are at higher risk of contracting tuberculosis. DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adolescence Adult Aged Aged, 80 and over Antibodies, Protozoan/BLOOD Carrier State Female Hepatitis B/*COMPLICATIONS Hepatitis B Surface Antigens/ANALYSIS Human HIV Antibodies/BLOOD Malaria/*COMPLICATIONS Male Middle Age Risk Factors Tuberculosis/*COMPLICATIONS JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).